Acemannan (Aloe vera Leaf Polysaccharide)
Acemannan (the active compound in Aloe vera) has been proven to accelerate wound healing by activation of mTOR signalling pathway and cell proliferation via inducing cyclin D1 translation . In skincare, this is excellent for promoting healthy cell turnover to reduce fine lines, wrinkles and age spots. Acemannan has also been proven to protect mice against radiation-induced death, and has potential for use as a therapeutic agent for radiation damage . We are exposed to radiation daily through alpha, beta and gamma rays in the environment.
(1) Wei et al. (2015). Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. J. of Dermatological Science. 79 (2); 101-109.
(2) Kumar S and Tiku AB (2016). Immunomodulatory potential of acemannan (polysaccharide from Aloe vera) against radiation induced mortality in Swiss albino mice. J. of Food and Agricultural Immunology. 27 (1); 72-86.